Reprogramming of metabolic development by restriction of fetal growth.

نویسنده

  • C T Jones
چکیده

Mason, R. .I. (1982) in Lung Det9elopment: triological and Clinical Perspecrives (Farrell, P. M., ed.), vol. I , pp. 135-150, Academic Press, New York Mason, R. J. & Nellenboaen, J . (1982) Fed. Proc. Fed. Am. SOC. E.xp. Biol. 41, 1600 Okano. G. & Akino, T. (1978) Biochim. Biophj.s. Acta 528, 373 384 Oldenborg, V . & Van Golde, L. M. G . (19'76) Biochim. Biophys. Acta 441, 433442 Possmayer, F. (1984) in Pulmonary Su$u:fac.funt (Robertson, B., Van Golde. L. M. G . & Batenburg. J . J.. eds.). pp. 295-355. Elsevier Biomedical Press, Amsterdam Post, M., Batenburg, J . J., Schuurmans, E. A . J . M. & Van Golde, L. M. G. (1982) Biochim. Biophys. Acta 712, 390-394 Post, M., Schuurmans, E. A. J. M., Batenburg, J . J . & Van Golde, L. M. G . (1983) Biochini. Biophys. Acta 750, 68-77 Post, M., Batenburg, J . J.. Smith, B. T. & Van Golde. L. M. G. (1984a) Biochim. Biophjs. Acfa 795, 552 557 Post, M., Batenburg, J . J . , Van Golde, L. M. G. & Smith, B. T. (1984h) Biochim. Bioph~'.~. Acta 795, 558-563 Rooney, S. A. (1983) in The Biological Basis of Reproductitw and Decelopmental Medicine (Warshaw, J. B., ed.), pp. 239-287, Elsevier Biomedical, New York Vance, D. E. & Pelech, S. L. (1984) Trends Biochem. Sci. 9, 17-20

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Placental metabolic reprogramming: do changes in the mix of energy-generating substrates modulate fetal growth?

Insufficient oxygen leads to the cessation of growth in favor of cellular survival. Our unique model of high-altitude human pregnancy indicates that hypoxia-induced reductions in fetal growth occur at higher levels of oxygen than previously described. Fetal PO(2) is surprisingly high and fetal oxygen consumption unaffected by high altitude, whereas fetal glucose delivery and consumption decreas...

متن کامل

The maternal, fetal and postnatal somatotrophic axes in intrauterine growth retardation.

Both the maternal and fetal somatotrophic axes are closely linked to fetal substrate supply. Nutritional insults at critical stages of fetal development may lead to permanent reprogramming of the relationships between these factors. The consequences of reprogramming during fetal life may be harmful to metabolic, endocrine and cardiovascular homoeostatic mechanisms in postnatal life. The exact m...

متن کامل

Intrauterine Growth Restriction: Hungry for an Answer.

Intrauterine growth restriction (IUGR) has been defined in several ways, but in general describes a condition in which the fetus exhibits poor growth in utero. This complication of pregnancy poses a significant public health burden as well as increased morbidity and mortality for the offspring. In human IUGR, alteration in fetal glucose and insulin homeostasis occurs in an effort to conserve en...

متن کامل

MRI detection of asymmetric intrauterine growth restriction due to placental insufficiency

Purpose: Intrauterine growth restriction (IUGR) is defined as a fetus that is not maintaining its genetic growth potential in utero. This reduced growth is often caused by placental insufficiency resulting in decreased nutrient and oxygen supply to the fetus. To increase the likelihood of survival, fetal adaptations occur, which include brain sparing leading to asymmetric growth restriction, al...

متن کامل

I-12: Nuclear Reprogramming in Bovin Somatic Cell Nuclear Transfer

Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...

متن کامل

Comparison of Maternal Serum and Umbilical Cord Blood Leptin Level in IUGR Neonates

Background: Gestational weight gain is an impressive factor in the fetal outcome. Intrauterine growth restriction (IUGR) is one of the most important problems during fetal period that may lead to many perinatal and long-term complications and growing neonatal morbidities and mortalities. The aim of the study was to ascertain the relationship between umbilical cord blood leptin concentration and...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Biochemical Society transactions

دوره 13 1  شماره 

صفحات  -

تاریخ انتشار 1985